New Modes of Action for Endocrine-Disrupting Chemicals
نویسندگان
چکیده
منابع مشابه
New modes of action for endocrine-disrupting chemicals.
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that mimic or block the transcriptional activation elicited by naturally circulating steroid hormones by binding to steroid hormone receptors. For example, the Food Quality Protection Act of 1996 defines EDC as those, that "may have an effect in humans that is similar to an effect produced by a naturally occurring estr...
متن کاملEndocrine disrupting chemicals
The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...
متن کاملDefinition, classification and mechanism of action of endocrine disrupting chemicals.
Address for correspondence: Prof. Dr. Wolfgang Wuttke, Department of Endocrinology, University Medical Center Goettingen, Georg-AugustUniversity, Robert-Koch-Strasse 40, D-37099 Goettingen/ Germany, Tel.: +49-551-396714, Fax: +49-551-396518, E-mail: [email protected] Received 10-11-09, Revised 12-12-09, Accepted 2 -12-09
متن کاملEndocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action
The incidence and/or prevalence of health problems associated with endocrine-disruption have increased. Many chemicals have endocrine-disrupting properties, including bisphenol A, some organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, pesticides, polycyclic aromatic hydrocarbons, alkylphenols, solvents, and some household products including s...
متن کاملDirect action of endocrine disrupting chemicals on human sperm.
Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, the...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2006
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2004-0513